Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments.

@article{Guilloux2011CharacterizationO5,
  title={Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments.},
  author={Jean-Philippe Guilloux and Denis J David and Lin Xia and Hai Thanh Nguyen and Quentin Rainer and Bruno P. Guiard and Christelle Rep{\'e}rant and Thierry Deltheil and Mikl{\'o}s T{\'o}th and Ren{\'e} Hen and Alain Michel Gardier},
  journal={Neuropharmacology},
  year={2011},
  volume={61 3},
  pages={478-88}
}
Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment of generalized anxiety disorder in Humans. However, because only few animal models display overt anxious-like behavior, detailed preclinical studies of the anxiolytic properties of antidepressants are still lacking. Here, we studied the neurochemical and behavioral effects of a double 5-HT(1A/1B) receptor knockout in mice (5-HT(1A/1B)-/-) as compared to their wild-type littermates (5-HT(1A/1B)+/+). It is… CONTINUE READING
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