Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target.

@article{Saggu2017CharacterizationO4,
  title={Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target.},
  author={Gagandeep Singh Saggu and Shilpi S Garg and Zarna Rajeshkumar Pala and Sushil Kumar Yadav and Sanjay Kumar Kochar and Dhanpat Kumar Kochar and Vishal Saxena},
  journal={International journal of biological macromolecules},
  year={2017},
  volume={96},
  pages={
          466-473
        }
}
The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the sole process of isoprenoids biosynthesis in the parasite and is different from that in humans. Among the seven enzymes known to be functional in the MEP pathway in prokaryotes, most enzymes from Plasmodium are yet uncharacterized. The penultimate enzyme of this pathway 4-hydroxy-3-methylbut-2-en-1-yl diphosphate… CONTINUE READING
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