Characterization of 4-aminopyridine block of the transient outward K+ current in adult rat ventricular myocytes.

@article{Castle1993CharacterizationO4,
  title={Characterization of 4-aminopyridine block of the transient outward K+ current in adult rat ventricular myocytes.},
  author={Neil A Castle and Mara T. Slawsky},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 3},
  pages={1450-9}
}
The blocking action of 4-aminopyridine (4-AP) on the transient outward K+ current (ITO) in isolated rat ventricular myocytes was studied using the whole-cell configuration of the patch-clamp technique. 4-AP inhibition of ITO was concentration-dependent with half-maximal block occurring at 0.2 mM. At high concentrations (> 1 mM), 4-AP appeared to slow both the activation and inactivation phases of ITO. This resulted in a crossover phenomenon where in the presence of 4-AP the outward current was… CONTINUE READING

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