Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate.

@article{Elo1996CharacterizationO1,
  title={Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate.},
  author={Jussi P Elo and Lateef A Akinola and Matti Poutanen and Pirkko Vihko and Atte P. Kyll{\"o}nen and Olavi Lukkarinen and Reijo Vihko},
  journal={International journal of cancer},
  year={1996},
  volume={66 1},
  pages={37-41}
}
In the present study, expressions of 17beta-hydroxysteroid dehydrogenase (17HSD) types 1, 2, and 3, 5alpha-reductase type 2 and human androgen receptor mRNAs were determined in 12 benign prostatic hyperplasia and 17 prostatic carcinoma specimens. 17HSD type 2 was found to be the principle isoenzyme expressed in the prostate. Significantly higher expressions of 17HSD type 2 and 5alpha-reductase type 2 were detected in benign prostatic hyperplasia compared with the carcinoma specimens. Expression… CONTINUE READING

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