Characterization of β-catenin expression in canine osteosarcoma.

  title={Characterization of β-catenin expression in canine osteosarcoma.},
  author={Timothy J. Stein and K. Holmes and Anantharaman Muthuswamy and Victoria Thompson and Michael K. Huelsmeyer},
  journal={Veterinary and comparative oncology},
  volume={9 1},
Osteosarcoma (OSA) is the most frequently occurring malignant primary bone tumour in dogs and children and arises from cells of the osteoblast lineage. Inappropriate Wnt signalling activity has been implicated in human OSA. Altered expression of β-catenin, an integral member of the Wnt signalling pathway, has been associated with numerous human cancers, including OSA. In this study, 30 of the 37 primary canine OSA tissues and 2 of the 3 metastatic OSAs were positive for β-catenin expression as… CONTINUE READING