Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist.

@article{Calo2000CharacterizationO,
  title={Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist.},
  author={Girolamo Calo' and Remo Guerrini and Raffaella Bigoni and Anna Rizzi and G Giuliano Marzola and Hideo Okawa and Clementina Bianchi and D G Lambert and Severo Salvadori and Domenico Regoli},
  journal={British journal of pharmacology},
  year={2000},
  volume={129 6},
  pages={1183-93}
}
1.. Nociceptin (orphanin FQ) is a novel neuropeptide capable of inducing a variety of biological actions via activation of a specific G-protein coupled receptor. However, the lack of a selective nociceptin receptor antagonist has hampered our understanding of nociceptin actions and the role of this peptide in pathophysiological states. As part of a broader programme of research, geared to the identification and characterization of nociceptin receptor ligands, we report that the novel peptide… CONTINUE READING
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