Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain.

@article{Levant1992CharacterizationO,
  title={Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain.},
  author={Beth Levant and D. G. E. Grigoriadis and E B Desouza},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={262 3},
  pages={929-35}
}
The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies of D2 receptor-mediated effects. In addition, quinpirole may have even higher affinity for the recently described D3 dopamine receptor. The present study describes the in vitro binding properties of newly developed [3H]quinpirole in rat brain. [3H]Quinpirole binding was characterized in striatal membrane homogenate preparations using a filtration assay… CONTINUE READING
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