Characterization of [3H]CGS 19755 binding sites in the rat spinal cord.

  title={Characterization of [3H]CGS 19755 binding sites in the rat spinal cord.},
  author={Martina Sandberg and A L Ask and Christopher J Fowler},
  journal={Neurochemistry international},
  volume={24 4},
[3H]Cis-4-phosphonomethyl-2-piperidine carboxylic acid ([3H]CGS 19755) was used to investigate the pharmacology and characteristics of the N-methyl-D-aspartate (NMDA) receptor recognition site from Triton X-100-treated membranes of rat spinal cord and cerebral cortex. The association of [3H]CGS 19755 was biphasic in both spinal cord and cerebral cortical membranes reaching a maximum after 5 min of incubation then decreasing to a steady level after an additional 10 min, suggesting that a… CONTINUE READING


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