Corpus ID: 31319434

Characterization and viral safety validation study of a pasteurized therapeutic concentrate of antithrombin III obtained through affinity chromatography.

@article{Biescas1998CharacterizationAV,
  title={Characterization and viral safety validation study of a pasteurized therapeutic concentrate of antithrombin III obtained through affinity chromatography.},
  author={H. Biescas and M. Gensana and J. Fern{\'a}ndez and P. Ristol and M. Massot and E. Watson and F. Vericat},
  journal={Haematologica},
  year={1998},
  volume={83 4},
  pages={
          305-11
        }
}
BACKGROUND AND OBJECTIVE Antithrombin III (ATIII) concentrates are employed as therapy for congenital or acquired deficiencies. These concentrates are obtained from Cohn's fraction IV1. To improve yields, purity and safety, our group developed a procedure to obtain a pasteurized ATIII concentrate from the supernatant of Cohn's fraction II + III including a highly efficient heparin affinity chromatography purification and pasteurization as a viral inactivation step. DESIGN AND METHODS Three… Expand
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Robustness of nanofiltration for increasing the viral safety margin of biological products.
Virus safety of intravenous immunoglobulin
The Use of Chromatography to Manufacture Purer and Safer Plasma Products
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