Characterization and time dependence of amphotericin B: deoxycholate aggregation by quasielastic light scattering.

@article{LamyFreund1991CharacterizationAT,
  title={Characterization and time dependence of amphotericin B: deoxycholate aggregation by quasielastic light scattering.},
  author={Maria Teresa Lamy-Freund and Shirley Schreier and Robert M. Peitzsch and Wayne F. Reed},
  journal={Journal of pharmaceutical sciences},
  year={1991},
  volume={80 3},
  pages={
          262-6
        }
}
Quasielastic light scattering measurements of amphotericin B (AB):deoxycholate (DOC) preparations provided information about particle size and aggregation as a function of concentration. The data allowed the time dependence of the aggregation to be followed and indicated that the initial rates of the change in average equivalent hydrodynamic diameter increased with decreasing concentration. The results extend the model proposed by Lamy-Freund and co-workers, which describes AB:DOC systems as… CONTINUE READING
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