Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.

@article{ArtavanisTsakonas2010CharacterizationAS,
  title={Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.},
  author={Katerina Artavanis-Tsakonas and Wilhelm Andreas Weihofen and John M. Antos and Bradley Coleman and Christy A Comeaux and Manoj Duraisingh and Rachelle Gaudet and Hidde L. Ploegh},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 9},
  pages={6857-66}
}
Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its activity and changes in active site architecture upon binding to ubiquitin. We find strong evidence that PfUCHL3 is essential to parasite survival. The crystal structures of both PfUCHL3 alone and in complex with the ubiquitin-based suicide substrate UbVME suggest a rather rigid active site… CONTINUE READING

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