Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.

@article{Jones2009CharacterizationAS,
  title={Characterization and sequence analysis of extended-spectrum-\{beta\}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.},
  author={Carolyn H Jones and Margareta Tuckman and David F. Keeney and Alexey V Ruzin and Patricia A Bradford},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 2},
  pages={465-75}
}
In concert with the development of novel beta-lactams and broad-spectrum cephalosporins, bacterially encoded beta-lactamases have evolved to accommodate the new agents. This study was designed to identify, at the sequence level, the genes responsible for the extended-spectrum-beta-lactamase (ESBL) phenotypes of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during the global tigecycline phase 3 clinical trials. PCR assays were developed to identify and clone… CONTINUE READING

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