Characterization and regulation of the mouse insulin receptor substrate gene promoter.

@article{Araki1995CharacterizationAR,
  title={Characterization and regulation of the mouse insulin receptor substrate gene promoter.},
  author={Eiichi Araki and Burritt Haag and Kohji Matsuda and Motoaki Shichiri and C. Ronald Kahn},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 10},
  pages={
          1367-79
        }
}
To evaluate the potential for regulation of the insulin receptor substrate IRS-1, we have cloned the mouse IRS-1 gene, identified its promoter, and analyzed promoter activity in the basal state and in response to stimulation. The 5'-region of the mouse IRS-1 gene lacks typical CAAT and TATA boxes but contains nine potential Sp1 binding sites consistent with a housekeeping gene. The 5'-region of the IRS-1 gene also has significant regions of homology with the promoters of the progesterone… 
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