Characterization and regulation of p-aminobenzoic acid synthase from Streptomyces griseus.

@article{Gil1985CharacterizationAR,
  title={Characterization and regulation of p-aminobenzoic acid synthase from Streptomyces griseus.},
  author={Jos{\'e} Luis Ad{\'a}n Gil and Germ{\'a}n Naharro and Julio R. Villanueva and Juan F. Martin},
  journal={Journal of general microbiology},
  year={1985},
  volume={131 6},
  pages={1279-87}
}
p-Aminobenzoic acid synthase (PABA synthase) of Streptomyces griseus catalyses the conversion of chorismic acid to p-aminobenzoic acid (PABA), a precursor of the aromatic p-aminoacetophenone moiety of candicidin, a polyene macrolide antibiotic. This enzyme uses glutamine or ammonia as amino donors for PABA formation. Enzyme extracts converted [14C]chorismic acid to labelled PABA. PABA synthase was present in S. griseus IMRU 3570 only during the antibiotic producing phase. No detectable levels… CONTINUE READING

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