Characterization and regulation of epidermal growth factor receptors in human placental cell cultures.


We have confirmed that cultured human placental cells rapidly release hCG. Preincubation with epidermal growth factor (EGF) for 24 h significantly increased the amount of hCG released and also increased human placental lactogen release by these cells. To better understand the mechanisms of action of EGF on the feto-placental unit, we studied EGF receptor… (More)