Characterization and quantitative analysis of DNA adducts formed from lower chlorinated PCB-derived quinones.

@article{Zhao2004CharacterizationAQ,
  title={Characterization and quantitative analysis of DNA adducts formed from lower chlorinated PCB-derived quinones.},
  author={Shouxun Zhao and Amarjit Singh Narang and Xinxin Ding and George Eadon},
  journal={Chemical research in toxicology},
  year={2004},
  volume={17 4},
  pages={
          502-11
        }
}
Polychlorinated biphenyls are wide pollutants readily detected in environmental and human specimens. DNA adduction occurs through the corresponding quinones. Polychlorinated biphenyls are first metabolized to arene oxides, which can be further oxidized to dihydroxy metabolites by microsomal cytochrome p450s. The catechol and hydroquinone products are further oxidized by peroxidases to quinones, which are electrophilic and capable of reacting with DNA to form adducts. DNA adduction is initiated… CONTINUE READING

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