Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex.

Abstract

BACKGROUND Accumulating evidence indicates that isoflurane and other, similarly acting anesthetics exert neurotoxic effects in neonatal animals. However, neither the identity of dying cortical cells nor the extent of cortical cell loss has been sufficiently characterized. We conducted the present study to immunohistochemically identify the dying cells and… (More)
DOI: 10.1213/ANE.0b013e318281e988

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