Characterization and primary structures of bovine and porcine thyroxine-binding globulin.

@article{Janssen2002CharacterizationAP,
  title={Characterization and primary structures of bovine and porcine thyroxine-binding globulin.},
  author={Onno Eilard Janssen and Harald Lahner and Helmut Grasberger and Sabine A Spring and Bernhard Saller and Klaus Mann and Samuel Refetoff and Ralf Einspanier},
  journal={Molecular and cellular endocrinology},
  year={2002},
  volume={186 1},
  pages={27-35}
}
Thyroxine-binding globulin (TBG) is the major serum transport protein for iodothyronines in most of the large, omni- or herbivorous mammals. Characterization of human TBG (hTBG), including its 20 known natural variants, allowed the identification of the ligand-binding site and a correlation of diminished synthesis or loss of function with mutations in the TBG gene. Further refinement of the structure-function correlation, especially the high binding affinity and heat stability, requires… CONTINUE READING