Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption.

Abstract

Supersaturatable self-emulsifying drug delivery systems (S-SEDDS) were explored to improve the oral absorption of AMG 517, a poorly water-soluble drug candidate. In vitro characterizations indicate the level of Tween 80 in the formulation dictates the initial degree of supersaturation of AMG 517, and, therefore, its precipitation kinetics. The presence of a… (More)
DOI: 10.1002/jps.21451

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@article{Gao2009CharacterizationAO, title={Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption.}, author={Ping Gao and Anna Akrami and Francisco Javier Delgado Alvarez and Jack Hu and Lan Li and Chandra Ma and Sekhar Surapaneni}, journal={Journal of pharmaceutical sciences}, year={2009}, volume={98 2}, pages={516-28} }