Characterization and molecular cloning of a Cu/Zn superoxide dismutase from the human parasite Onchocerca volvulus.

@article{Henkle1991CharacterizationAM,
  title={Characterization and molecular cloning of a Cu/Zn superoxide dismutase from the human parasite Onchocerca volvulus.},
  author={K J Henkle and Eva Liebau and Sylke M{\"u}ller and B{\"a}rbel Bergmann and Rolf D. Walter},
  journal={Infection and immunity},
  year={1991},
  volume={59 6},
  pages={2063-9}
}
Evidence suggests that the helminth antioxidant enzyme superoxide dismutase (SOD) may play a role in parasite's defense against the cellular immune mechanisms of the host. In order to investigate this for the human parasite Onchocerca volvulus, the enzyme activity was characterized, the release of SOD by the parasite was examined, and a complete cDNA encoding the O. volvulus SOD was identified. The SOD activity in adult O. volvulus was found to be 8.1 +/- 4.2 U/mg of protein. A Cu/Zn-containing… CONTINUE READING

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