Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells.

@article{Gingras2003CharacterizationAM,
  title={Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells.},
  author={S{\'e}bastien Gingras and Carl Turgeon and Nancy Brochu and Penny Soucy and Fernand Labrie and Jacques Simard},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2003},
  volume={87 2-3},
  pages={167-79}
}
Skin, the largest organ of the human body, synthesizes active sex steroids from adrenal C19 precursor steroids. Normal human breast epidermal keratinocytes in primary culture were used to evaluate the enzymatic activities responsible for the formation and degradation of active androgens and estrogens during keratinocyte differentiation. Enzymatic activities, including 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), 5alpha… CONTINUE READING
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