Characterization and manipulation of the human adenovirus 4 genome.

  title={Characterization and manipulation of the human adenovirus 4 genome.},
  author={Susan C Jacobs and Andrew J Davison and Sharon Carr and Alice M Bennett and Robert J Phillpotts and Gavin W G Wilkinson},
  journal={The Journal of general virology},
  volume={85 Pt 11},
Human adenovirus 4 (HAdV-4), the only serotype of the species HAdV-E to be isolated from man, was first identified by its association with outbreaks of acute respiratory disease in military recruits. To combat such outbreaks, a live, oral HAdV-4 vaccine that is delivered via an enteric-coated capsule was developed. This vaccine has been used for nearly 40 years and has been shown to be safe and efficacious. In this study, the complete DNA sequence (35 994 bp) of the vaccine strain is described… CONTINUE READING


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Family Adenoviridae. In Virus Taxonomy: Seventh Report of the International Committee on Taxonomy of Viruses, pp. 227–238

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  • 2000
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