Characterization and localization of a 77 kDa protein related to the dystrophin gene family.

@article{Fabbrizio1994CharacterizationAL,
  title={Characterization and localization of a 77 kDa protein related to the dystrophin gene family.},
  author={Eric Fabbrizio and Uri Nudel and G{\'e}rald Hugon and Agn{\'e}s Robert and Françoise Pons and Dominique Mornet},
  journal={The Biochemical journal},
  year={1994},
  volume={299 ( Pt 2)},
  pages={359-65}
}
The Duchenne muscular dystrophy gene gives rise to transcripts of several lengths. These mRNAs differ in their coding content and tissue distribution. The 14 kb mRNA encodes dystrophin, a 427 kDa protein found in muscle and brain, and the short transcripts described encode DP71, a 77 kDa protein found in various organs. These short transcripts have many features common to the deduced primary structure of dystrophin, especially in the cysteine-rich specific C-terminal domains. The dystrophin C… CONTINUE READING