Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord.

@article{Chow2000CharacterizationAI,
  title={Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord.},
  author={S Y Chow and J M Moul and Christopher A Tobias and B Timothy Himes and Yi Liu and Maria Obrocka and Linda Hodge and Alan R Tessler and Itzhak Fischer},
  journal={Brain research},
  year={2000},
  volume={874 2},
  pages={87-106}
}
Recent advances in the isolation and characterization of neural precursor cells suggest that they have properties that would make them useful transplants for the treatment of central nervous system disorders. We demonstrate here that spinal cord cells isolated from embryonic day 14 Sprague-Dawley and Fischer 344 rats possess characteristics of precursor cells. They proliferate as undifferentiated neurospheres in the presence of EGF and bFGF and can be maintained in vitro or frozen, expanded and… CONTINUE READING