Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation.

@article{Chiu2012CharacterizationAI,
  title={Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation.},
  author={Ya-Fang Chiu and Bill Sugden and P Chang and Lee-Wen Chen and Ying-Ju Lin and Yu-Ching Lan and Chih-Ho Lai and Jieh-Yuan Liou and S Liu and C F Hung},
  journal={Journal of virology},
  year={2012},
  volume={86 18},
  pages={9647-55}
}
Epstein-Barr virus (EBV) BBLF1 shares 13 to 15% amino acid sequence identities with the herpes simplex virus 1 UL11 and cytomegalovirus UL99 tegument proteins, which are involved in the final envelopment during viral maturation. This study demonstrates that BBLF1 is a myristoylated and palmitoylated protein, as are UL11 and UL99. Myristoylation of BBLF1 both facilitates its membrane anchoring and stabilizes it. BBLF1 is shown to localize to the trans-Golgi network (TGN) along with gp350/220, a… CONTINUE READING

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