Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.

  title={Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.},
  author={J E Lennard Jones and Corey P. Causey and Leslie L Lovelace and Bryan A Knuckley and Heather Flick and Lukasz Lebioda and Paul R Thompson},
  journal={Bioorganic chemistry},
  volume={38 2},
Helicobacter pylori encodes a potential virulence factor, agmatine deiminase (HpAgD), which catalyzes the conversion of agmatine to N-carbamoyl putrescine (NCP) and ammonia - agmatine is decarboxylated arginine. Agmatine is an endogenous human cell signaling molecule that triggers the innate immune response in humans. Unlike H. pylori, humans do not encode an AgD; it is hypothesized that inhibition of this enzyme would increase the levels of agmatine, and thereby enhance the innate immune… CONTINUE READING


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