Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.

@article{Jones2010CharacterizationAI,
  title={Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.},
  author={J E Lennard Jones and Corey P. Causey and Leslie L Lovelace and Bryan A Knuckley and Heather Flick and Lukasz Lebioda and Paul R Thompson},
  journal={Bioorganic chemistry},
  year={2010},
  volume={38 2},
  pages={62-73}
}
Helicobacter pylori encodes a potential virulence factor, agmatine deiminase (HpAgD), which catalyzes the conversion of agmatine to N-carbamoyl putrescine (NCP) and ammonia - agmatine is decarboxylated arginine. Agmatine is an endogenous human cell signaling molecule that triggers the innate immune response in humans. Unlike H. pylori, humans do not encode an AgD; it is hypothesized that inhibition of this enzyme would increase the levels of agmatine, and thereby enhance the innate immune… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Oral Microbiol

A. R. Griswold, M. M. Nascimento, R. A. Burne
Immunol. 24 (1) • 2009
View 4 Excerpts
Highly Influenced

D

X. Lu, L. Li, +9 authors B. M. Martin
Dunaway-Mariano, Biochemistry 45 (4) • 2006
View 6 Excerpts
Highly Influenced

FEBS Lett

T. Janowitz, H. Kneifel, M. Piotrowski
544 (1-3) • 2003
View 10 Excerpts
Highly Influenced

Grafit Version 5.0.11

R. J. Leatherbarrow
Erathicus Software, • 2004
View 3 Excerpts
Highly Influenced

Gastroenterology 133 (3) (2007) 985–1001

N. Vakil, F. Megraud
J.E. Jones et al. / Bioorganic Chemistry 38 • 2010
View 2 Excerpts

Med

F. Liao, Z. Li, +3 authors X. Cheng
Hypotheses 72 (6) • 2009
View 1 Excerpt

Neurosci

C. H. Su, I. M. Liu, H. H. Chung, J. T. Cheng
Lett. 457 (3) • 2009
View 1 Excerpt

I

C. Wolf, M. Bruss, B. Hanisch, M. Gothert
von Kugelgen, G.J. Molderings, Mol. Pharmacol. 71 (1) • 2007
View 1 Excerpt

M

S. Baumann, A. Sander, J. R. Gurnon, G. M. Yanai-Balser, J. L. Van Etten
Piotrowski, Virology 360 (1) • 2007

Chem

Y. Luo, B. Knuckley, +3 authors J. Am
Soc. 128 (45) • 2006

Similar Papers

Loading similar papers…