Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer.

@article{Nkolola2014CharacterizationAI,
  title={Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer.},
  author={Joseph P. Nkolola and Christine A Bricault and Ann Cheung and Jennifer L. Shields and J. Randolph Perry and James M. Kovacs and Elena E. Giorgi and Margot van Winsen and Adrian Apetri and Els C. M. Brinkman-Van der Linden and Bing Chen and Bette T Korber and Michael S. Seaman and Dan H Barouch},
  journal={Journal of virology},
  year={2014},
  volume={88 17},
  pages={
          9538-52
        }
}
UNLABELLED The extraordinary diversity of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein poses a major challenge for the development of an HIV-1 vaccine. One strategy to circumvent this problem utilizes bioinformatically optimized mosaic antigens. However, mosaic Env proteins expressed as trimers have not been previously evaluated for their stability, antigenicity, and immunogenicity. Here, we report the production and characterization of a stable HIV-1 mosaic M… CONTINUE READING

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