Characterization and immunogenicity of EX880, a Salmonella typhi Ty21a-based clone which produces Vibrio cholerae O antigen.

@article{Attridge1991CharacterizationAI,
  title={Characterization and immunogenicity of EX880, a Salmonella typhi Ty21a-based clone which produces Vibrio cholerae O antigen.},
  author={Stephen R. Attridge and C E Dearlove and Lisa Beyer and Luisa Van den Bosch and A Howles and Jennifer A. Hackett and Renato Morona and Justin T Labrooy and Derrick Rowley},
  journal={Infection and immunity},
  year={1991},
  volume={59 7},
  pages={2279-84}
}
EX645 is a derivative of Salmonella typhi Ty21a which carries a plasmid specifying production of Vibrio cholerae O antigen. When cultured with exogenous galactose to overcome the galE defect of the vector, EX645 also synthesizes S. typhi O antigen, and this can result in the masking of the shorter V. cholerae O antigen on the bacterial surface. To determine whether the potential for such masking at least partly underlies the inconsistency of anti-V. cholerae responses elicited by EX645, a… CONTINUE READING