Characterization and functionality of cell surface molecules on human mesenchymal stem cells.

@article{Majumdar2003CharacterizationAF,
  title={Characterization and functionality of cell surface molecules on human mesenchymal stem cells.},
  author={Manas K. Majumdar and Michele Keane-Moore and Diana Buyaner and Wayne B Hardy and M Allison Moorman and Kevin Mcintosh and Joseph D. Mosca},
  journal={Journal of biomedical science},
  year={2003},
  volume={10 2},
  pages={228-41}
}
We have characterized adhesion molecules on the surface of multipotential human mesenchymal stem cells (hMSCs) and identified molecules whose ligands are present on mature hematopoietic cells. Flow cytometric analysis of hMSCs identified the expression of integrins: alpha1, alpha2, alpha3, alpha5, alpha6, alphav, beta1, beta3, and beta4, in addition to ICAM-1, ICAM-2, VCAM-1, CD72, and LFA-3. Exposure of hMSCs to IL-1alpha, TNFalpha or IFNgamma up-modulated ICAM-1 surface expression, whereas… CONTINUE READING
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