Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment.

@article{Calfa2003CharacterizationAF,
  title={Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment.},
  author={Gast{\'o}n Diego Calfa and Silvia ME Kademian and Danilo Guillermo Ceschin and Gemma Vega and Gabriel A. Rabinovich and Marta Volosin},
  journal={Psychoneuroendocrinology},
  year={2003},
  volume={28 5},
  pages={687-701}
}
Hyperactivity of the hypothalamic pituitary adrenal (HPA) axis in patients with major depression is one of the most consistent findings in biological psychiatry. Experimental data support the idea that glucocorticoid-mediated feedback via glucocorticoid receptors (GR) is impaired in major depression. The aim of the present work was to assess the putative changes in GR density of peripheral blood mononuclear cells (PBMCs) in a group of patients with major depression and to determine modulation… CONTINUE READING