Characterization and function of putative substrate specificity domain in microvirus external scaffolding proteins.

@article{Uchiyama2007CharacterizationAF,
  title={Characterization and function of putative substrate specificity domain in microvirus external scaffolding proteins.},
  author={Asako Uchiyama and Min Chen and Bentley A. Fane},
  journal={Journal of virology},
  year={2007},
  volume={81 16},
  pages={
          8587-92
        }
}
Microviruses (canonical members are bacteriophages phiX174, G4, and alpha3) are T=1 icosahedral virions with an assembly pathway mediated by two scaffolding proteins. The external scaffolding protein D plays a major role during morphogenesis, particularly in icosahedral shell formation. The results of previous studies, conducted with a cloned chimeric external scaffolding gene, suggest that the first alpha-helix acts as a substrate specificity domain, perhaps mediating the initial coat-external… CONTINUE READING

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