Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.

@article{Chertova2013CharacterizationAF,
  title={Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.},
  author={Elena N Chertova and Cristina Bergamaschi and Oleg Chertov and Raymond C. Sowder and Jenifer Bear and James D. Roser and Rachel Kelly Beach and Jeffrey D Lifson and Barbara K Felber and George N Pavlakis},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 25},
  pages={
          18093-103
        }
}
Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor α (sIL-15Rα). Here, we show efficient production of this noncovalently linked but stable heterodimer in clonal human HEK293 cells and release of the processed IL-15·sIL-15Rα heterodimer in the medium. Purification of the IL-15 and sIL-15R… CONTINUE READING
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