Characterization and expression of the pepsinogen C gene and determination of pepsin-like enzyme activity from orange-spotted grouper (Epinephelus coioides).

@article{Feng2008CharacterizationAE,
  title={Characterization and expression of the pepsinogen C gene and determination of pepsin-like enzyme activity from orange-spotted grouper (Epinephelus coioides).},
  author={Shaozhen Feng and Wensheng Li and Hao Lin},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2008},
  volume={149 2},
  pages={275-84}
}
One pepsinogen C gene was cloned from the gastric mucosa of orange-spotted grouper (Epinephelus coioides) for the first time. This gene consisted of nine exons interrupted by eight introns. The nucleotide sequence with the coding region and 3'-flanking region was also determined. The deduced polypeptide sequence was composed of a prosegment of 55 residues and a pepsin moiety of 332 residues. The putative substrate-binding subsites were well conserved among fish with the exception of the residue… CONTINUE READING

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