Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase (GILT) gene in rainbow trout (Oncorhynchus mykiss) with implications for GILT in innate immune response

@article{Liu2013CharacterizationAE,
  title={Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase (GILT) gene in rainbow trout (Oncorhynchus mykiss) with implications for GILT in innate immune response},
  author={Meng Liu and Hongyan Liu and Xiaocui Guan and Hongxin Ai and Haitao Wu and Ping Liu and Wei Gu and Shuang-quan Zhang},
  journal={Immunogenetics},
  year={2013},
  volume={65},
  pages={873-882}
}
The interferon-γ-inducible lysosomal thiol reductase (GILT) has been demonstrated to play an important role in the processing and presentation of MHC class II-restricted antigen (Ag) by catalyzing disulfide bond reduction. In this study, a rainbow trout cDNA (designated as rGILT) was cloned and identified from Oncorhynchus mykiss. The open reading frame of rGILT consists of 759 bases encoding a protein of 253 amino acids with an estimated molecular mass of 28.23 kDa and a theoretical… CONTINUE READING
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