Characterization and expression of NADPH oxidase in LPS-, poly(I:C)- and zymosan-stimulated trout (Oncorhynchus mykiss W.) macrophages.

@article{Boltaa2009CharacterizationAE,
  title={Characterization and expression of NADPH oxidase in LPS-, poly(I:C)- and zymosan-stimulated trout (Oncorhynchus mykiss W.) macrophages.},
  author={Sebasti{\'a}n Bolta{\~n}a and Carmen Do{\~n}ate and Frederick William Goetz and Simon A. Mackenzie and Joan Carles Balasch},
  journal={Fish & shellfish immunology},
  year={2009},
  volume={26 4},
  pages={651-61}
}
In vertebrates, the generation of superoxide reactive oxygen species (ROS) via activation of the Nox/Duox family of NADPH oxidases is a prototypical feature of the pathogen-induced defensive responses of activated professional phagocytes. To understand the role of the rainbow trout (Oncorhynchus mykiss) Phox oxidase from a phylogenetic and functional perspective we describe the cloning, sequencing and expression analysis of multiple NADPH components in cultured macrophages. Phylogenetic… CONTINUE READING