Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15.

@article{Blechingberg2012CharacterizationAE,
  title={Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15.},
  author={Jenny Blechingberg and Ida Elisabeth Holm and Anders Lade Nielsen},
  journal={Gene},
  year={2012},
  volume={493 1},
  pages={27-35}
}
The FET protein family consists of FUS (TLS), EWS (EWSR1), and TAF15. The FET proteins bind DNA and RNA and are involved in transcriptional regulation and RNA processing. Translocations involving the FET genes have been identified in human sarcomas, and mutations in the FUS and TAF15 genes are associated with Amyotrophic Lateral Sclerosis. We here describe the characterization of the porcine FET proteins and an expression analysis during embryonic brain development. The FET proteins are well… CONTINUE READING

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