Characterization and experimental transmission of an oncogenic papillomavirus in female macaques.

@article{Wood2007CharacterizationAE,
  title={Characterization and experimental transmission of an oncogenic papillomavirus in female macaques.},
  author={Charles E. Wood and Zigui Chen and John Mark Cline and Brigitte E. Miller and Robert D Burk},
  journal={Journal of virology},
  year={2007},
  volume={81 12},
  pages={6339-45}
}
Cervical cancer is one of the leading causes of cancer mortality in women worldwide, yet few suitable animal models currently exist for study of this disease. Virtually all cases of cervical cancer in women are caused by specific types of genital human papillomavirus (HPV). In this study, we investigated naturally occurring genital PVs in female cynomolgus macaques (Macaca fascicularis) without breeding contact for at least 3.5 years. Exfoliated cervicovaginal cells from 19 of 54 animals tested… CONTINUE READING