Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp.

@article{Rochette2005CharacterizationAD,
  title={Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp.},
  author={Annie Rochette and François McNicoll and Joanne Girard and Marie Le Breton and Eric Leblanc and Michel G. Bergeron and Barbara Papadopoulou},
  journal={Molecular and biochemical parasitology},
  year={2005},
  volume={140 2},
  pages={
          205-20
        }
}
The ability of Leishmania amastigotes to survive within the drastic environmental changes encountered in the phagolysosomes of mammalian macrophages is heavily dependent on the developmental regulation of a variety of genes. The identification of genes that are expressed preferentially in the mammalian stage of the parasite should increase our understanding of the molecular mechanisms regulating stage-specific gene expression and of the determinants that control its intracellular survival and… CONTINUE READING
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