Characterization and developmental expression of a Drosophila ras oncogene.

  title={Characterization and developmental expression of a Drosophila ras oncogene.},
  author={Brian A Mozer and R L Marlor and Susan M Parkhurst and Victor G Corces},
  journal={Molecular and cellular biology},
  volume={5 4},
We cloned a Drosophila melanogaster ras gene (Dmras64B) on the basis of its homology to the ras oncogen from Harvey murine sarcoma virus. This gene mapped at chromosomal position 64B on the left arm of the third chromosome. Sequencing of Dmras64B revealed extensive amino acid homology with the proteins encoded by the human and Saccharomyces cerevisiae ras genes. The coding region of the Drosophila gene is interrupted by two introns located in different positions with respect to its human… CONTINUE READING