Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis.

@article{Balasubramani2011CharacterizationAD,
  title={Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis.},
  author={M. Balasubramani and Chitose Nakao and Guy T Uechi and John J Cardamone and K Ghanashyam Kamath and Kristen L Leslie and Raghavan Balachandran and Leslie Wilson and Billy W. Day and Mary Ann Jordan},
  journal={Mutation research},
  year={2011},
  volume={722 2},
  pages={154-64}
}
Stathmin/oncoprotein 18, a protein that regulates microtubule dynamics, is highly expressed in a number of tumors including leukemia, lymphoma, neuroblastoma, breast, ovarian, and prostate cancers. High stathmin levels have been associated with the development of resistance to the widely used anti-cancer drug taxol ((®)Taxol, paclitaxel). The mechanisms of stathmin-mediated taxol resistance are not well-understood at the molecular level. To better understand the role of stathmin in taxol… CONTINUE READING