Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall.

@article{Lizard1999CharacterizationAC,
  title={Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall.},
  author={G{\'e}rard Lizard and Serge Monier and Catherine Cordelet and Laurence Gesquiere and Val{\'e}rie Deckert and Serge Gueldry and Laurent Lagrost and Philippe Gambert},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 5},
  pages={1190-200}
}
Oxidized low density lipoproteins (LDLs) play a central role in atherosclerosis, and their toxicity is due, at least in part, to the formation of oxysterols that have been shown to induce apoptosis in various cell types. As 7beta-hydroxycholesterol and 7-ketocholesterol are the major oxysterols found in oxidized LDLs, we have investigated and compared the mode of cell death, apoptosis versus necrosis, that they induce in the cells of the vascular wall, ie, endothelial cells, smooth muscle cells… CONTINUE READING

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