Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.

@article{Purdue1991CharacterizationAC,
  title={Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.},
  author={P. Edward Purdue and Michael J. Lumb and Mark H Fox and G Griffo and C Hamon-Benais and Sue Povey and Christopher J. Danpure},
  journal={Genomics},
  year={1991},
  volume={10 1},
  pages={34-42}
}
We have previously reported the isolation of a genomic clone encoding human liver-specific peroxisomal alanine:glyoxylate aminotransferase (AGT, EC 2.6.1.44), the deficient enzyme in primary hyperoxaluria type 1 (PH1) (P. E. Purdue, Y. Takada, and C. J. Danpure, J. Cell Biol. 111: 2341-2351, 1990). This clone has now been characterized, revealing that the coding sequence is distributed among 11 exons covering 10 kb. The nucleotide sequences of each exon have been determined, confirming that… CONTINUE READING

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