Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea

  title={Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea},
  author={S{\o}ren Vig Lehmann and Ulla Hoeck and Jens Breinholdt and Carl Erik Olsen and Bo Kreilgaard},
  journal={Contact Dermatitis},
For several decades, the cosmetic preservatives imidazolidinyl urea (IU) and diazolidinyl urea (DU) have not only been poorly characterized but have also had misleading chemical structures assigned to them. The most common trade names of IU and DU are Germall 115 and Germall II, respectively. This publication gives an insight into what these 2 well‐known contact allergens consist of and their degradation patterns. Approximately, 30–40% of both products can be characterized by mixtures of… 

Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea

Although the complete ingredient list of the hydrogels tested was not able to get, attending to these observations could be of importance to evaluate the presence of IU/DU in patients with suspected contact dermatitis to hydrogel.

Sulfonamides with Heterocyclic Periphery as Antiviral Agents

This review provides examples of the synthesis of sulfonamide compounds with antiviral properties that can be used to develop drugs against coxsackievirus B, enteroviruses, encephalomyocarditis viruses, adenovirus, human parainfluenza viruses, Ebola virus, Marburg virus, SARS-CoV-2, HIV and others.

The Release of Formaldehyde upon Decomposition of 2-Bromo-2-nitropropan-1, 3-diol (Bronopol)

We investigated the release of formaldehyde (FA) upon the decomposition of 2-bromo-2-nitropropan-1,3-diol (Bronopol: BP), an FA-releasing substance widely used as an antimicrobial preservative in

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To reduce NDELA, it is recommended that cosmetics be stored under cool/amber conditions and that Vit E or Vit C inhibitors of nitrosation be optimally added to cosmetic formulations at concentrations between 100 and 1000 µg/ml.

Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl‐urea or imidazolidinyl‐urea

The case of a girl reacting to several products containing diazolidinyl-urea and/or imidazolidinyurea is presented and patch test results to formaldehyde and other formaldehyde releasers were negative.

Effects of Several Cosmetic Preservatives on ROS-Dependent Apoptosis of Rat Neural Progenitor Cells

In rat NPCs, ROS production and cleaved caspase-8 expression were increased while the cell viability was decreased in high concentrations of these substances, suggesting that several cosmetic preservatives at high concentrations can induce neural toxicity in rat brains through ROS induction and apoptosis.

Development of a sustainable continuous flow approach toward allantoin

Allantoin is a commodity molecule widely used in cosmetic and pharmaceutical industry for its moisturizing properties. Although allantoin is a naturally occurring compound, its extraction is not

Toxicological and hygienic study of imidourea as antibacterial preservative for pharmaceutical and cosmetic products

Imidourea in the inhalation route of admission has a general toxic, sensitizing, weak antimicrobial effect and is recommended to use the ASLE in the air of the working area of 1.5 mg/m3 (aerosol).



Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches

A patch test concentration in hydrophilic dried‐in vehicle (TRUE Test) of 600 μg/cm2 was found to be adequate and safe for both IMID and DU.

Determination of imidurea in cosmetic products by capillary zone electrophoresis and miceliar electrokinetic chromatography

Capillary electrophoresis has been employed for the determination of imidurea (imidazolidinyl urea) in cosmetic preparations and the preservatives in several commercial products have been identified and quantitated.

Determination of diazolidinyl urea in cosmetic formulations by capillary electrophoresis

Capillary electrophoresis (CE) is demonstrated for the determination of the preservative diazolidinyl urea in cosmetic formulations. The extremely high resolving power of CE separates the compound

Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography.

A method for quantification of formaldehyde in the presence of formaldehyde donors in skin‐care products

The aim of this study was to develop a method that could be used in clinics and workplaces for quantification of free formaldehyde in products preserved with formaldehyde donors and the method developed is named the closed container diffusion (CCD) method.

Determination of free formaldehyde in the presence of donators in cosmetics by HPLC and post-column derivation

SummaryThe determination of free formaldehyde in the presence of its donators in cosmetic samples by a combination of reversed phase chromatography and post column reaction detection is described.

Germall II. A new broad spectrum cosmetic preservative

Concentrated solutions of preservatives: their technological and analytical advantages in cosmetic products

Introducing concentrated solutions of preservatives (CSP) provides a methodology both for the use of preservative systems and for their routine control in cosmetic products.