Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea

@article{Lehmann2006CharacterizationAC,
  title={Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea},
  author={S{\o}ren Vig Lehmann and Ulla Hoeck and Jens Breinholdt and Carl Erik Olsen and Bo Kreilgaard},
  journal={Contact Dermatitis},
  year={2006},
  volume={54}
}
For several decades, the cosmetic preservatives imidazolidinyl urea (IU) and diazolidinyl urea (DU) have not only been poorly characterized but have also had misleading chemical structures assigned to them. The most common trade names of IU and DU are Germall 115 and Germall II, respectively. This publication gives an insight into what these 2 well‐known contact allergens consist of and their degradation patterns. Approximately, 30–40% of both products can be characterized by mixtures of… 

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References

SHOWING 1-10 OF 24 REFERENCES

Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches

A patch test concentration in hydrophilic dried‐in vehicle (TRUE Test) of 600 μg/cm2 was found to be adequate and safe for both IMID and DU.

Determination of imidurea in cosmetic products by capillary zone electrophoresis and miceliar electrokinetic chromatography

Capillary electrophoresis has been employed for the determination of imidurea (imidazolidinyl urea) in cosmetic preparations and the preservatives in several commercial products have been identified and quantitated.

Determination of diazolidinyl urea in cosmetic formulations by capillary electrophoresis

Capillary electrophoresis (CE) is demonstrated for the determination of the preservative diazolidinyl urea in cosmetic formulations. The extremely high resolving power of CE separates the compound

Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography.

A method for quantification of formaldehyde in the presence of formaldehyde donors in skin‐care products

The aim of this study was to develop a method that could be used in clinics and workplaces for quantification of free formaldehyde in products preserved with formaldehyde donors and the method developed is named the closed container diffusion (CCD) method.

Determination of free formaldehyde in the presence of donators in cosmetics by HPLC and post-column derivation

SummaryThe determination of free formaldehyde in the presence of its donators in cosmetic samples by a combination of reversed phase chromatography and post column reaction detection is described.

Germall II. A new broad spectrum cosmetic preservative

Concentrated solutions of preservatives: their technological and analytical advantages in cosmetic products

Introducing concentrated solutions of preservatives (CSP) provides a methodology both for the use of preservative systems and for their routine control in cosmetic products.