Characterization and cancer cell specific binding properties of anti-EGFR antibody conjugated quantum dots.

@article{Lee2010CharacterizationAC,
  title={Characterization and cancer cell specific binding properties of anti-EGFR antibody conjugated quantum dots.},
  author={Junghan Lee and Youngseon Choi and Keumhyun Kim and Sukmin Hong and Hye-Young Park and Taesup Lee and Gi Jeong Cheon and Rita Song},
  journal={Bioconjugate chemistry},
  year={2010},
  volume={21 5},
  pages={940-6}
}
Synthesis of biologically active antibody conjugated quantum dots (QDs) has been of great importance in cellular imaging and diagnostics. Cetuximab (or Erbitux) is the first monoclonal antibody drug which targets the epidermal growth factor receptor (EGFR) overexpressed in most cancer cells. In the present work, we investigated three different conjugation strategies to obtain the biologically functional QD-cetuximab conjugates for the tumor-specific imaging. Successful conjugation of cetuximab… CONTINUE READING

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