Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.

@article{Iyer1998CharacterizationAB,
  title={Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.},
  author={Suhasini Iyer and Jacky Woo and Miguel Cornejo and L Gao and William McCoubrey and Massimiliano Maines and Roland Buelow},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 5},
  pages={2692-7}
}
This is the first report on peptidic inhibitors of heme oxygenase. Such peptides were originally developed from the immunomodulatory peptide 2702.75-84 which corresponds to amino acid residues 75 to 84 of the alpha1-helix of HLA-B2702 (2702.75-84) and has been shown to be immunosuppressive in vitro and in vivo. In vitro, 2702.75-84 inhibited cytotoxic T- and natural killer cell- mediated target cell lysis, and in vivo peptide therapy resulted in prolongation of heart and skin allograft survival… CONTINUE READING