Characterization and biological properties of a new staphylococcal exotoxin

  title={Characterization and biological properties of a new staphylococcal exotoxin},
  author={K Ren and Jason D Bannan and Vijaykumar Pancholi and Ambrose L. Cheung and John C. Robbins and Vincent A. Fischetti and John B. Zabriskie},
  journal={The Journal of Experimental Medicine},
  pages={1675 - 1683}
Staphylococcus aureus strain D4508 is a toxic shock syndrome toxin 1-negative clinical isolate from a nonmenstrual case of toxic shock syndrome (TSS). In the present study, we have purified and characterized a new exotoxin from the extracellular products of this strain. This toxin was found to have a molecular mass of 25.14 kD by mass spectrometry and an isoelectric point of 5.65 by isoelectric focusing. We have also cloned and sequenced its corresponding genomic determinant. The DNA sequence… CONTINUE READING


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