Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.

@article{Mainelis2013CharacterizationAA,
  title={Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.},
  author={Gediminas Mainelis and Sriram Seshadri and Olga B. Garbuzenko and Tingting Han and Zhaoxuan Wang and Tamara Minko},
  journal={Journal of aerosol medicine and pulmonary drug delivery},
  year={2013},
  volume={26 6},
  pages={345-54}
}
BACKGROUND A small nose-only exposure chamber was evaluated for inhalation delivery of drug carrier systems (DCSs) to mice for the treatment of lung cancer. The chamber then was used for inhalation delivery of an anticancer drug, antisense oligonucleotides (ASO), and small interfering RNA (siRNA) directly to the cancerous lungs of mice. METHODS The… CONTINUE READING