Characterization and acceptor preference of a soluble meningococcal group C polysialyltransferase.

  title={Characterization and acceptor preference of a soluble meningococcal group C polysialyltransferase.},
  author={Dwight C. Peterson and Gayathri Arakere and Justine Vionnet and Pumtiwitt C McCarthy and Willie F. Vann},
  journal={Journal of bacteriology},
  volume={193 7},
Vaccines against Neisseria meningitidis group C are based on its α-2,9-linked polysialic acid capsular polysaccharide. This polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody serves to evade host defense mechanisms. The polysialyltransferase (PST) that forms the group C polysialic acid (NmC PST) is located in the cytoplasmic membrane. Until recently, detailed characterization of bacterial polysialyltransferases has been hampered by a lack of… CONTINUE READING
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