Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.

@article{Chan2016CharacterizationAS,
  title={Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.},
  author={Susanna T S Chan and Roger R. Nani and Evan A Schauer and Gary E. Martin and R Thomas Williamson and Josep Saur{\'i} and Alexei V Buevich and Wes A Schafer and Leo A Joyce and Andrew K. L. Goey and William D. Figg and Tanya T Ransom and Curtis J. Henrich and Tawnya Carlene McKee and Arvin Moser and Scott A MacDonald and Shabana Iqrar Khan and James Brislin McMahon and Martin J. Schnermann and Kirk R Gustafson},
  journal={The Journal of organic chemistry},
  year={2016},
  volume={81 22},
  pages={
          10631-10640
        }
}
An extract of Eudistoma sp. provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework. Eudistidine C (1) is a racemic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl group and a phenol-substituted aminoimidazole moiety. This compound presented significant structure elucidation challenges due to the large number of heteroatoms and fully substituted carbons. These issues were mitigated by application of a new NMR pulse… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…