Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems.

@article{Reiter2016CharacterizationAS,
  title={Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems.},
  author={Katherine H. Reiter and Anita Ramachandran and Xue Xia and Lauren E. Boucher and J{\"u}rgen Bosch and Michael J Matunis},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 8},
  pages={3860-70}
}
Protein modification by small ubiquitin-related modifiers (SUMOs) is essential and conserved in the malaria parasite, Plasmodium falciparum. We have previously shown that interactions between the SUMO E1-activating and E2-conjugating enzyme in P. falciparum are distinct compared with human, suggesting a potential target for development of parasite-specific… CONTINUE READING